Fisetin is a naturally occurring flavonol found in many fruits and vegetables with multiple benefits such as antioxidant, anticancer, and neuroprotective effects. Fisetin inhibits lipid accumulation and suppresses PPARγ expression in 3T3-L1 cells. Festerone inhibits the early stages of preadipocyte differentiation and induces Sirt1 expression. Fethersole promotes Sirt1-mediated deacetylation of PPARγ and FoxO1 and enhances Sirt1 binding to the PPARγ promoter, leading to inhibition of PPARγ transcriptional activity and consequently inhibition of adipogenesis. Fesphenazone binds to microtubule proteins and stabilises microtubules, and its binding properties are far superior to those of paclitaxel. Fesudone treatment of human prostate cancer cells resulted in strong upregulation of microtubule-associated protein (MAP)-2 and -4. Fesudone significantly inhibited PCa cell proliferation, migration and invasion. Nudc, a protein associated with the microtubule motility dynamics protein/ dynactin complex that regulates microtubule dynamics, was inhibited by treatment with fethersone .
The nemesis of tumours
Antioxidant and anti-inflammatory don't really count for much for the mighty laccasein, they are basic operations, fighting tumours is its arena. Lacin plays an inhibitory role in all stages of tumour development, using its "thunderbolt" means to govern the tumour in a submissive manner.
In the early stage of tumour development, lacosan can interfere with chromosome separation and promote DNA double-strand breaks, thus reducing its proliferation rate . During the rapid growth phase of tumours, laccase also reduces angiogenesis by inhibiting uPA (urokinase fibrinogen activator), cutting off the source of nutrients to the tumour. In the advanced stage of tumours, tumours may metastasize, and laccase can prevent the degradation of the ECM protein barrier by inhibiting MMP-1, a key target, thus preventing tumour cells from entering the bloodstream and inhibiting metastasis of tumour cells.
