What are the pharmacological effects of berberine?

Berberine is an alkaloid which is extracted from Chinese medicinal plants such as Coptis chinensis and Phellodendron amurense. The main dosage forms include berberine hydrochloride tablets and berberine hydrochloride capsules. Berberine has a weak antibacterial effect on bacteria. However, berberine is effective in the treatment of intestinal infections caused by some sensitive bacteria, such as dysentery bacillus and Escherichia coli. Therefore, berberine is indicated for the treatment of intestinal infections caused by E. coli and E. dysenteriae, such as bacillary dysentery and other diseases. However, the use of berberine may also produce some adverse effects, including symptoms such as nausea and vomiting, but these adverse effects usually disappear when the drug is discontinued. In addition, berberine tends to produce precipitates with substances such as tannins in tea, so tea should be avoided while taking berberine. In addition, berberine is not suitable for people who are allergic to the product or any of its inactive ingredients, patients with haemolytic anaemia, and patients with serosanguinosis. For pregnant women, berberine should be used with caution during the first 3 months.
Let's talk about the role of berberine in detail below
1, Antibacterial: Berberine has antibacterial effect on many kinds of Gram-positive and Gram-negative bacteria. It is found that berberine can have strong inhibitory effect on Staphylococcus aureus, Gonococcus, meningococcus, Shigella dysentery bacillus, Typhoid bacillus, Diphtheria bacillus, etc. It has antibacterial effect on many kinds of bacteria, and it has been widely used in the treatment of gastroenteritis and bacillary dysentery, etc. In addition, berberine is also effective in treating tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infections;
2、Lowering blood sugar: Current research has found that berberine also has the effect of lowering blood sugar, mainly through reducing body weight, improving glucose tolerance, and then lowering blood sugar;
3, regulating lipids: there are also studies found that berberine can effectively increase fat burning, at the same time, it can also reduce fat synthesis, which can be used to treat high blood fat.