Celastrol

Celastrol, also known as southern serpentine, is a natural product with a variety of biological activities, it has a strong antioxidant effect, anti-cancer neoangiogenesis, and anti-rheumatoid effect, mainly from the root bark of Celastrol, a plant of the family of the Weihuai family, which is one of the active ingredients in the preparations for the treatment of rheumatoid diseases such as Celastrol tablets and tretinoin polyside tablets.

The main activity and pharmacological effects of Lei Gongteng Hongxin:

1, Cytotoxic activity. It has strong non-specific cytotoxic activity against P388 and a group of human cancer cell lines in vitro.

2, Immunomodulatory effect. Significantly inhibited the formation of haemolytic vacuole cells in mouse splenocytes. Significantly inhibited delayed hypersensitivity reaction in mice.

3, Anti-inflammatory effect. 0.5mg/kg, significantly inhibited the formation of cotton ball granuloma in rats.0.1-1.0μg/mL at Chemicalbook, inhibited the production of PGE2 induced by yeast sugar; 1.0μg/mL, inhibited phagocytosis by macrophages.

4, The anti-peroxide effect of Celastrol is 15 times that of tocopherol, with an IC50 of 7 μM. It inhibits peroxidation inside and outside the mitochondrial membrane, and scavenges free radicals directly.

5, Celastrol prolongs the sleep time of mice induced by sodium pentobarbital.

6, Immunosuppressive effects: inhibits splenocyte proliferation and lymphocyte proliferation induced by PHA, ConA, and LPS, etc., in mice.

7, Suppresses in vitro spermatozoa fertilisation in guinea-pigs, and the activity is Significantly stronger than the activity of acetate of cotton wool.

8, Anti-arthritic effect. Inhibit the activity of interleukin-1 inside and outside of mouse peritoneal macrophages, inhibit the production of interleukin-2 by mouse splenocytes, and reduce the release of PGE2 from rabbit synovial cells.

Selasetron, a traditional Chinese medicine in China, has been widely used in the treatment of many primary and secondary renal diseases, especially in the field of clinical treatment of refractory nephrotic syndrome due to its strong anti-inflammatory, immunosuppressive and podocytoprotective effects.

It has shown unique advantages and is regarded as the best choice for clinical treatment of refractory nephrotic syndrome. Understanding the pharmacology, toxicity and side effects of Celastrol, and mastering the correct precautions and reasonable application methods can help reduce the adverse reactions of this drug and give full play to its clinical efficacy.

Modern research has confirmed its anti-inflammatory, immunosuppressive and anti-tumour effects, and it has shown its unique efficacy in the field of rheumatic immune diseases and renal diseases, especially refractory nephropathy.

Founded in 2014, Sanyi Chemical has 300 to 350 employees. The company integrates production, sales and service. It focuses on plant extracts, active ingredient monomers, plant powders, natural fruit and vegetable powders, and is dedicated to plant extracts. It is a professional company in R&D and production. Strong technical force, annual output of 500 tonnes, product specifications and stable quality.