Because of the presence of phenolic hydroxyl groups on the molecule of lignocaine, its aqueous solution shows weak acidity. Lignocaine can generate colourful complexes with metal ions such as iron, magnesium, calcium, copper, aluminium, zirconium, etc. For example, the following complexation reaction can occur with iron ions. The redox property of lignocaine was studied by cyclic voltammetry, and it was found that lignocaine in dimethylformamide (DMF) had one more oxidation peak than that in ethyl cyanide, and the potential of other peaks shifted significantly. The results showed that the solvent has a great influence on the electrochemical properties of lignocaine.
High Purity
Luteolin can be obtained in high purity through natural extraction and fine manufacturing processes. High purity means better bioavailability and fewer adverse reactions.
Safety
Luteolin extract is a natural product that has been proven to be safe for humans. There are no toxic side effects within the dosage range.
Stability
Luteolin has good stability and can maintain its activity and effect under different environmental and storage conditions.
Easily absorbed
Luteolin can be rapidly absorbed by the human body, entering the blood circulation through the intestines and distributed to different tissues and organs.
Anti-inflammatory
The anti-inflammatory activity of lignans is related to the inhibition of nitric oxide (NO) and other inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) production, inhibition of phosphorylation of the protein complexin and nuclear transcripxion factor KB (NF-KB)-mediated gene expression.
01
Anti-tumour
Lignans mainly rely on changing the cell signalling pathway to inhibit tumour cell growth factors or change the kinase activity to resist the infiltration of cancer cells, but also through the blockage of the cell cycle and other ways to inhibit the growth of tumour cells. It can regulate lipid peroxidation, antioxidant, antiproliferative.
02
Anti-allergic
Lignocaine can inhibit immunoglobulin E (IgE)-mediated human mast cell production of allergic transmitters, including histamine, leukotrienes, prostaglandin D2, and the release of monocyte macrophage colony-stimulating factor, and its effect may be related to the inhibition of Ca2 inward flow and protein kinase C (PKC) translocation activation.
03
Anti-inflammatory demyelinating diseases
Lignocaine can dose-dependently protect oligodendrocytes against hydrogen peroxide-induced oxidative damage in vitro, strongly inhibit macrophage phagocytosis of myelin, significantly reduce the production of cellular reactive oxygen species clusters, reduce the expression of iNOS proteins, and markedly reduce the level of NO produced by macrophages at low doses.
04
Anti-fibrosis
Lignocaine can reduce the degree of hepatic fibrosis, reduce the content of hydroxyproline (HYP), malondialdehyde (MDA) and the expression of type I pre-collagen mRNA in liver tissues, and inhibit the proliferation of hepatic stellate cells (HSC) and collagen synthesis in vitro. It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce the lung weight index, significantly reduce the elevation of MDA, HYP, and inhibit the expression of mRNA of transforming growth factor-β1 (TGF-β1) in lung tissues, and inhibit the proliferation of human embryonic lung fibroblasts in vitro, and promote their apopxosis.
05
Lowering uric acid (anti-uric acid high)
Lignans as natural flavonoids, have the characteristics of inhibiting xanthine oxidase activity, thus playing a role in inhibiting the generation of uric acid, in addition, there are experiments that show that lignans in the dose of 100mg.kg-1, there is a significant promotion of uric acid excretion of the role of uric acid.
06
Anti-fertility and hormone effect
Lignocaine has a significant dose-dependent anti-implantation activity, after oral administration can significantly increase the weight of the uterus, diameter, endometrial thickness and the height of its epithelial cells, when applied alone with estrogen-like effect, but and ethinyl estradiol combined with the anti-estrogen effect is shown.
07
Actions on blood vessels
Lignocaine can inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis in rabbit cornea in vivo; it can inhibit tumour growth and angiogenesis in murine xenograft tumour model; it can inhibit the survival and proliferation of human umbilical vein vascular endothelial cells (HUVECs) induced by VEGF in vitro.
08
Gout attack is an acute inflammatory reaction. As uric acid crystals accumulate in the joints, the inflammation will produce redness, heat, swelling, and pain, etc. The most common areas are the knee, ankle, and finger and toe joints, which usually affects the normal mobility, and in serious cases, it may lead to infection. In an animal experiment, individual experiments supplemented with ingredients such as lignocaine, colchicine and MSU to compare the reactions after gout attacks, and it was found that the experimental group supplemented with lignocaine could effectively improve the inflammatory reactions such as redness, heat, swelling, and pain caused by gout in 6 hours, and had the effect of relieving gouty attacks, which is expected to be an effective medicine for the treatment of acute gouty arthritis.
Founded in 2014, Sanyi Chemical has 300 to 350 employees. The company integrates production, sales and service. It focuses on plant extracts, active ingredient monomers, plant powders, natural fruit and vegetable powders, and is dedicated to plant extracts. It is a professional company in R&D and production. Strong technical force, annual output of 500 tonnes, product specifications and stable quality.
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Molecular Formula: C13H8O4
Formula Weight: 228.2
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Apply: Dietary supplements
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Apply: Pharmaceuticals,Intermediates
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