Nobiletin Extract Powder 98%

Nobiletin powder is derived from the rutaceae Citrus nobilis Lour. rind, lime C. aurantium L. rind, mandarin C. reticulata Blanco leaves, stems. Alias: Kawapitin, Honeylocustin

Nobiletin powder, NOB, is a retinoid acid recepxor-related orphan recepxor, ROR, activator, and the team pre-identified Sichuan chenpianin, which improves the body's circadian rhythm oscillation and maintains metabolic homeostasis. However, it is unclear whether maintaining circadian rhythm stability is beneficial in delaying organismal aging. This study explored the role of NOB in the regulation of bioenergetics and metabolic changes in mouse skeletal muscle, and found that the NOB-ROR axis improves the activity and function of the mitochondrial respiratory complex, thereby delaying skeletal muscle aging. This finding provides a pharmacological strategy to delay aging by modulating the bioenergetics and metabolic levels.

Effects of NOB on Organismal Aging and Circadian Rhythms.

After 20 weeks of NOB intervention in aged mice on a normal diet, the researchers found that NOB prolonged the average lifespan of the mice and was able to prolong their average sleep time.

NOB prolongs survival and mean sleep time in mice.

NOB-ROR can modulate Bmal1, Npas2, in skeletal muscle.

The mechanism by which the circadian rhythm-targeting drug NOB delays aging, i.e., the NOB-ROR axis opximises mitochondrial respiration by up-regulating circadian rhythm-related genes in skeletal muscle, as well as modulating gene expression of the mitochondrial respiratory complex. This study identifies a novel small molecule drug that can delay aging, as well as reveals a novel molecular mechanism by which biological rhythms are involved in the regulation of aging, providing a new perspective for delaying human aging.

Founded in 2014, Sanyi Chemical has 300 to 350 employees. The company integrates production, sales and service. It focuses on plant extracts, active ingredient monomers, plant powders, natural fruit and vegetable powders, and is dedicated to plant extracts. It is a professional company in R&D and production. Strong technical force, annual output of 500 tonnes, product specifications and stable quality.