Can spermidine treat hypopigmentation?

Hypopigmentation is a skin disease, mainly manifested by the reduction of melanin, common symptoms include vitiligo, albinism and hypopigmentation after skin inflammation. Currently, the main treatment for hypopigmentation is oral medication, but oral medication can cause skin atrophy, gastrointestinal discomfort and other adverse side effects. Therefore, it is necessary to develop a natural substance to treat hypopigmentation without side effects.

Difference between ectoin and boswellin.

Fisetin

The nemesis of tumours？

Fisetin is a naturally occurring flavonol found in many fruits and vegetables with multiple benefits such as antioxidant, anticancer, and neuroprotective effects. Fisetin inhibits lipid accumulation and suppresses PPARγ expression in 3T3-L1 cells. Festerone inhibits the early stages of preadipocyte differentiation and induces Sirt1 expression.

Super antioxidant ergothioneine

Super antioxidant ergothioneine L-Ergothioneine is a natural antioxidant and a unique cellular physiological protector with various physiological functions such as scavenging free radicals, whitening, anti-aging, preventing UV radiation damage, maintaining DNA synthesis and normal cell growth, etc. It was first discovered in 1909 by Charles Tanret in his study of ergot fungus (L-Ergothioneine, EGT). L-Ergothioneine (EGT) was first discovered by Charles Tanret in 1909 when he was studying ergot fungus, and later it was also found in mushrooms and cyanobacteria. L-Ergothioneine (EGT) cannot be synthesised by plants and animals themselves, but can only be obtained through external sources, and its physiological activities are indispensable to plants and animals.EGT exists in two structural isomers, thiol and thione, in the dissolved state. At physiological pH, EGT exists mainly as a thione in aqueous solution. Therefore, compared with other naturally occurring thiols (e.g., glutathione, N-acetylcysteine), EGT is a very stable antioxidant and is not susceptible to spontaneous oxidation at physiological pH. Ergothioneine can enter cells and mitochondria through the transporter OCTN-1 in keratinocytes and fibroblasts, directly scavenging reactive oxygen radicals and acting as an antioxidant to protect mitochondrial DNA. Ergothioneine can be used in skin care products for the following purposes: 1. Whitening Ergothioneine is a natural antioxidant that is highly protective and non-toxic to cells and is not easily oxidised in water, which allows them to reach a concentration of 7mmol/L in some tissues and stimulate the natural antioxidant defence system of cells. Research results show that the addition of ergothioneine in cosmetics up to 0.01%-0.03% can hinder pigment formation and deposition and whiten the skin. 2. Antioxidant: Highly effective antioxidant to slow down aging. L'Oreal has applied for a patent entitled "Use of ergothioneine and/or its derivatives as an anti-glycation agent", proposing that ergothioneine and its derivatives have the effect of reducing or even preventing the glycation of proteins, thus preventing the age-related loss of skin elasticity and repairing the skin. Age-related loss of skin elasticity, modification and improvement of facial contours, as well as stopping or improving the appearance of cellulite. 3. Sun Protection Ergothioneine acts as a physiological filter for UV light as it has similar absorption wavelengths to DNA in the UV absorption range, minimising the formation of reactive oxygen species and protecting cells from radiation damage. It has been shown in several papers that ergothioneine can avoid the damage to the skin caused by ultraviolet radiation, which is a very effective sunscreen ingredient. 4. Anti-inflammatory, acne relief Inflammation is the body's response when the skin is infected. Excessive UV exposure and stress are all triggers of skin inflammation. Studies have shown that ergothioneine can play an anti-inflammatory role in skin cells, and at the same time, combined with vitamin C will get more significant results. Elizabeth Arden has done the application of ergothioneine for UV-induced skin inflammation repair experiment, the surface of Idebenone and ergothioneine can reduce the UV-induced skin inflammation and photodamage. 5. Synergistic effect Ergothioneine can regulate intracellular redox reactions, participate in intracellular energy regulation, and is a physiological protective agent for cells, with biological and pharmacological properties and its safety and stability. Therefore, adding ergothioneine to a product can not only maintain the stability of other ingredients, but also promote the absorption of active ingredients by cells, which has a very good synergistic effect and effectively enhances the efficacy of other ingredients, achieving the effect of 1+1>2. For example, if ergothioneine is used in an antioxidant product, not only can it play a strong antioxidant role by itself, but it can also synergise with other antioxidants to enhance their vitality. Pur Sulfaine comes from bio-fermentation technology, pure and natural, with high content, strong activity and good efficacy, suitable for use in lightening and brightening, moisturising and firming, anti-ageing, anti-wrinkle and other functional skin care products.

Olive oil stimulates aldehydes that kill cancer cells without damaging healthy cells?

Olive oil-stimulating aldehydes rupture the lysosomes in cancer cells, which are the equivalent of the cancer cell's bin, thereby releasing the proteins that cause cancer cells to die.

What are the pharmacological effects of berberine?

What are the pharmacological effects of berberine? Berberine is an alkaloid which is extracted from Chinese medicinal plants such as Coptis chinensis and Phellodendron amurense. The main dosage forms include berberine hydrochloride tablets and berberine hydrochloride capsules. Berberine has a weak antibacterial effect on bacteria. However, berberine is effective in the treatment of intestinal infections caused by some sensitive bacteria, such as dysentery bacillus and Escherichia coli. Therefore, berberine is indicated for the treatment of intestinal infections caused by E. coli and E. dysenteriae, such as bacillary dysentery and other diseases. However, the use of berberine may also produce some adverse effects, including symptoms such as nausea and vomiting, but these adverse effects usually disappear when the drug is discontinued. In addition, berberine tends to produce precipitates with substances such as tannins in tea, so tea should be avoided while taking berberine. In addition, berberine is not suitable for people who are allergic to the product or any of its inactive ingredients, patients with haemolytic anaemia, and patients with serosanguinosis. For pregnant women, berberine should be used with caution during the first 3 months.

Can urolithin A reverse aging and boost immunity?

I. The Amazing Discovery of Urocitin A The leader of the research team, Dr Nicola Vannini, led an elite team in an unprecedented study in which they discovered that urolithin A reverses the senescent phenotype of ageing haematopoietic stem cells. This discovery was so important that it was published in the highly regarded journal Nature Aging.